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The present review ultimately weighs early concerns against increasingly consistent evidence that GLP-1 RA use does not raise overall cancer risk, clarifies that breast cancer risk appears neutral, and further highlights key mechanisms, such as the reduction of hyperinsulinemia and immune-microenvironment modulation, through which these drugs may improve rather than exacerbate malignancy outcomes

Lancet Gastroenterol Hepatol 2023;8:17991.ArticlePubMed 82

Approximately 2242% of patients with CAD also suffer from PAD

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After noticing about half of users stop taking GLP-1s shortly after starting treatment, Al-Aly wanted to understand the consequences of discontinuing GLP-1 medications on cardiovascular health, particularly the risk of major adverse cardiovascular events, including heart attack, stroke and death

No differences in safety or effectiveness were observed between these patients and younger patients