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Physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug

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They were the first in class approved for the management of overweight and obesity, says Rothberg

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[DOI] [PubMed] [Google Scholar] 51.Renstrm E, Eliasson L, Rorsman P

We also describe the potential of available and emerging treatment strategies to target metabolic remodelling in the setting of AF and highlight key questions and challenges that need to be addressed to improve outcomes in these patients