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The negative impact extends beyond the oral pill

An optimized GLP-1/CCK fusion had enhanced efficacy to lower body weight in obese rodents relative to mono-agonist controls and their co-administration [946,947]

Mice in which CD26 has been deleted showed increased levels of plasma GLP-1 (67)

However, large-scale randomized controlled trials specifically testing GLP-1 use for IBS remain limited, so evidence is considered promising but preliminary at this time

Pure GLP-1 agonists like semaglutide work excellently and represent a good starting point for most people

Genesis Health Clubs helps GLP-1 users build strength, improve body composition, and create a fitness routine that supports lasting results
