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Average body weight reduction at 72 weeks in the SURMOUNT-1 trial

no hepatic safety signal has been observed across the orforglipron clinical program, distinguishing it from the discontinued Pfizer oral GLP-1 candidates lotiglipron and danuglipron, both of which were terminated due to liver toxicity concerns

Store in a refrigerator between 2 C and 8 C

Research Reference Educational ranges and titration schedules reported in published studies

If pregnancy occurs, discontinue immediately

the product solution of Preparation 27 is collected and sent through a nanofiltration with 70/30 DMSO/ACN solution to remove reagents for 10-20 diavolumes