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Description
Studies in human and mouse islets lacking functional K ATP channels have demonstrated that the effect on plasma glucose is at least in part mediated by inhibition of insulin secretion resulting from lower cytoplasmic cAMP levels
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In addition, they had a reduced chance of relapse, even when exposed to cues associated with taking the drug, the drug itself, and stressors that tend to trigger drug-seeking behavior
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showed no differences in the frequency of symptomatic hypoglycemic events or severe hypoglycemia (62)
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