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Recent systematic analyses highlighted both sequence polymorphisms and epigenetic modifications (promoter methylation) as contributors to heterogeneous treatment outcomes, underscoring a multifactorial genetic architecture rather than a single predictive marker [27-29]
The American Society of Anesthesiologists has issued specific guidelines around this
The research spans regions including Asia-Pacific, Western Europe, and North America, covering countries such as the USA, UK, China, and Germany
