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In an additional, 30-week placebo-controlled, study of patients with type 2 diabetes inadequately controlled with metformin comparing the maintenance of sitagliptin 100 mg versus withdrawal of sitagliptin when initiating basal insulin therapy, the event rate and incidence of documented symptomatic hypoglycemia (blood glucose measurement 70 mg/dL) did not differ between the sitagliptin and placebo groups

How PlexusDx Supports a More Personalized Approach PlexusDx's precision-wellness model recognizes that GLP-1 eligibility is not determined by weight alone but by a combination of clinical biomarkers, metabolic risk factors, and individual health goals

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Moreover, increased proximal tubular glucose reabsorption disrupts normal tubuloglomerular feedback, further amplifying intraglomerular pressures [25]

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