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SGLT-2i pairs, GLP-1RA therapy was associated with higher risks of HSV (HR=1.387, 95% CI=1.2491.539) and HZ (HR=1.294, 95% CI=1.2031.392) compared to DPP-4i and HSV (HR=1.277, 95% CI=1.1321.442) and HZ (HR=1.18, 95% CI=1.0851.284) compared to SGLT-2i