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Semaglutide can influence how your body handles fluid balance, but the relationship between GLP-1 therapy and water retention is more nuanced than simple yes or no

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It works by increasing levels of key brain chemicals like norepinephrine, dopamine, and serotonin, which can help suppress appetite, reduce emotional eating, and support sustained daily energy.

Do not use if pregnant or nursing, have a medical condition or are taking medication

Results Four head-to-head randomized controlled studies with 1755 patients were included