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But Mounjaro and Zepbound also mimic a second hormone called glucose-dependent insulinotropic polypeptide (GIP)

That lipidation is what enables once-weekly dosing by extending the molecule's half-life from minutes to approximately seven days, but it also introduces manufacturing complexity that goes far beyond the peptide backbone itself

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[DOI] [PubMed] [Google Scholar] 40.Campbell I

mean duration of type 2 diabetes, 14.9 years)