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As the native GLP-1 has a short half-life, GLP-1 analogues have been produced to prolong effects and many of them could cross blood-brain barriers (BBB) such as Liraglutide (LG), lixisenatide, and exendin-4

Low, but physiological, concentration of GLP-1 stimulates insulin secretion independent of the cAMPdependent protein kinase pathway

Enteroendocrine l cells sense LPS after gut barrier injury to enhance GLP-1 secretion