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These views are not necessarily endorsed or verified by the National Academy of Medicine or the National Academies of Sciences, Engineering, and Medicine and should not be construed as reflecting any group consensus

DISCLOSURES: The authors have no conflict of interest to declare

This switching of G protein pathways elucidates a potential mechanism for basal insulin secretion under pharmacological treatment and provides an important direction for incretin-based therapies in type 2 diabetes

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