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Tirzepatide is a once-weekly injectable medication, FDA-approved under the brand name Mounjaro to treat type 2 diabetes and FDA-approved under the brand name Zepbound for weight loss

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The present study (Nicholls et al, 2025) SURPASS-CVOT (Study of Tirzepatide Compared with Dulaglutide on Major Cardiovascular Events in Participants with Type 2 Diabetes) was a double-blind, randomised, active-comparator study to determine non-inferiority of tirzepatide 15 mg (or highest tolerated dose) versus dulaglutide 1.5 mg in terms of 3-point MACE, in people aged 50 years with type 2 diabetes and established CVD