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76 , 81 In a recent study, we discovered that the SGLT-2i dapagliflozin might cross the BBB and interact with SGLT-2 in the brain

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15 Furthermore, there was no significant relationship between the change in left atrial volume and change in KCCQ-CSS postrandomization with semaglutide vs placebo

If you experience severe nausea, vomiting, abdominal pain, or inability to tolerate food or fluids after resuming semaglutide, contact your healthcare provider immediately, as these symptoms could indicate either medication intolerance or a postoperative complication requiring evaluation

10.1152/ajpendo.00665.2010 59

The discussion highlights challenges in PE trial design, the critical importance of clinical deterioration as an endpoint, and why this era represents an unprecedented wave of evidence generation in PE
