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GLP-1 receptor agonists (GLP-1RAs) show clinical promise, and the prevailing hypothesis is that their benefits are primarily driven by weight loss and the downstream benefits of improved functional status

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Regarding safety, gastrointestinal adverse eventsincluding nausea, vomiting, diarrhea, and constipationwere common with all therapies

These benefits span multiple biological systems including the nervous, musculoskeletal and respiratory systems

The injectable drug, initially only used as diabetes medication, is the first drug since Saxenda (2014) approved to treat chronic weight management in the 70% of American adults who are obese or overweight.

These gastrointestinal effects are usually mild to moderate in severity and occur most often during the dose escalation period before gradually decreasing over time