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As further GIP-GLP-1 receptor co-agonists were developed those findings were confirmed [51]

Likewise, another study shows that Exenatide alleviates mitochondrial dysfunction and cognitive impairment in 5FAD mice (84)

Additionally, while the daily oral form may be preferable to weekly injections, research suggests that adverse events occur more frequently with oral semaglutide

Finally, one can foresee a future where combination therapy becomes common: for example, a patient with diabetes and obesity might be on both a GLP-1 RA and an SGLT2 inhibitor (for complementary weight loss and cardio-renal protection, which is already done)
doi: 10.1126/scitranslmed.3007218, 30

Tirzepatide (weekly dual GIP + GLP-1 agonist
