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Weeks 5 to 8: The adjustment stretch By the second month many people have stepped up a dose and are starting to feel the appetite effect more clearly

You may get dehydrated during prolonged illness

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Note that this medication turns urine bright orange, which is normal and expected

TK, AL, DV, NK, AT and EB contributed to interpretation of data

Importantly, the Sema + -MSTN/-ActA group which had similar body weight reduction but increased lean mass compared to Sema alone also had markedly greater losses in fat mass, almost twice that seen with Sema alone (Fig