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Purity: 96% Example-2 Process for the preparation of Semaglutide by using solution phase peptide synthesis approach Step-A Fmoc-Gln(Trt)-Ala-Ala-Lys(C18 diacid mono-t-butyl-y-Glu(AEEA-AEEA)-OtBu)- Glu(OtBu)-Phe-Ile-Ala-Trp(Boc)-OFi (Fragment-4) was dissolved in DMF and stirred for 10 minutes at 25-30C

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This single case suggests that semaglutide may be associated with the development of pancreatic insufficiency in patients with possible chronic pancreatitis related to chronic alcohol abuse