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Several guidelines currently recommend GLP-1 RAs as add-on therapy to almost all diabetic treatments (with the exception of dipeptidyl peptidase-4 [DPP-4] inhibitors) and even as monotherapy to those intolerant to metformin

Among over 500 obese patients with OSAS, long-term tirzepatide treatment led to significant reductions in body weight, AHI, and oxygen desaturation index, with particularly pronounced benefits in patients with concurrent glucose and lipid metabolism abnormalities (52)

#PharmaIndustry #GLP1 #PatentCliff #ObesityTreatment #DiabetesCare #IndianPharma #Biologics This is a sharp analysis of why the GLP-1 race is a 'capability' play rather than just a 'commodity' play, especially given the high barriers in peptide API manufacturing and device calibration

2 Overview of -blockers and their classification The mechanism of action of -blockers involves their competitive antagonism of adrenergic stimulation of beta-adrenoceptors through structural similarities to catecholamines, which stimulate beta-adrenoceptors (1, 2 and 3) as well as alpha-adrenoceptors (1 and 2)