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GLP-1R activation is associated with decreased activity of the NF-B pathway [42], which orchestrates a wide range of stress-related inflammatory responses and controls the growth, survival, and development of many cell types

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They are usually transient, typically starting during the dose-escalation period and generally resolving shortly after the maintenance dose is reached, and, in most cases, they are mild to moderate in severity

Participants who received orforglipron started the study at a dose of 1 milligram daily and then increased the dose every four weeks to their final maintenance dose