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(Right) GLP-1 receptor agonist (GLP-1RA) reduces cholesterol accumulation by affecting the expression of genes in the hepato-enteral circulation and cholesterol reverse transport pathway, such as farnesoid X receptor (FXR), fibroblast growth factor-15 (FGF15), fibroblast growth factor receptor 4 (FGFR4), cytochrome P450 family 7 subfamily A member 1 (Cyp7a1), proprotein convertase subtilisin/kexin type 9 (PCSK9), low-density lipoprotein receptor (LDLR), etc

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doi: 10.1161/HYPERTENSIONAHA.111.175315

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Pharmacokinetics Absorption and Bioavailability: Oral administration of sitagliptin is rapidly absorbed, with peak plasma concentrations (Tmax) reached after 1 to 4 hours