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Intriguingly, a blockade of central estrogen receptors reduces the effect of a GLP-1R analog (exendin-4) on food-motivated behavior in both sexes, indicating that estrogen may modulate the effects of GLP-1 analogs not only in females but also in males (40)

That said, the Wegovy HD 7.2mg dose (approved March 2026) produced 20.7% in the STEP UP trial, which puts it very close to tirzepatide territory

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