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Common Reconstitution Mistakes to Avoid Many patients accidentally use non-sterile water or regular saline instead of bacteriostatic water, which introduces contaminants and increases infection risk

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SURMOUNT-5 also noted that weight loss was approximately 6% lower in men than women in both treatment groups but men on tirzepatide still do very well in absolute terms

The fact that it is not yet standard for GLP-1 users reflects the lower, though still elevated, risk level

In the SURMOUNT-1 trial, tirzepatide produced about 20.9% mean body-weight loss at 15 mg over 72 weeks