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Desensitization of GLP-1Rmediated cAMP responses after a first initial exposure of cells to GLP-1 was strictly dependent on the extent of phosphorylation with no, intermediate, or maximum phosphorylation observed in the presence of one, two, or three of the serine doublet phosphorylation sites, respectively

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Cardiovascular and renal outcomes with SGLT-2 inhibitors versus GLP-1 receptor agonists in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and network meta-analysis