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This can also lead to stimulation of the sympathetic nervous system and downregulation of parasympathetic tone via the vagus nerve through the dorsal motor nucleus of the vagus

Women with IIH also have twice the risk of cardiovascular disease than those of similar weight without IIH, but again, the pathophysiology underlying this is still not known [5]

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Conversely, people who already present with high anhedonia, for instance, in the context of a depressive illness, may see their symptoms worsening when on GLP-1RAswhich could elucidate some of the studies reporting negative effects associated with these medications in mood and anxiety disorders

While four studies assessed macronutrient composition, results were inconsistent, leaving unanswered questions about whether GLP-1 induced reductions in dietary protein or other nutrients contribute to observed changes in body composition