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Thiazolidinediones (TZDs) and neuroprotection TZDs, including pioglitazone and rosiglitazone (which are often referred to by the broader term thioglitazones [TZDs]), are a class of medications primarily used to treat type 2 diabetes

In general, type 1 diabetes raises special safety concerns because ketoacidosis risk can be higher

Combining physical activity with a balanced diet is recommended for maximum weight management effectiveness

While occasional muscle cramps are common and often benign, persistent or severe cramping may indicate electrolyte imbalances, peripheral neuropathy, or other underlying conditions requiring specific treatment

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It is also FDA approved to lower the risk of major adverse cardiovascular events (such as heart attack, stroke, and death) in adults with both Type 2 diabetes and cardiovascular disease