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Early research suggested that combining GIP with GLP-1 could have greater benefits than using GLP-1 alone

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Percent change in the WOMAC pain and physical function subscale scores were not pre-specified and were estimated from a post-hoc analysis

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The findings from this study suggest that people taking tirzepatide were able to eat much less and lose weight, possibly without much cognitive effort. Martin and colleagues conducted a phase 1, parallel-arm randomized controlled trial enrolling 114 adults with overweight or obesity