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When cortisol stays elevated, it can interfere with the SCFA-driven signals and the circadian timing that normally support healthy GLP-1 activity, which may leave appetite harder to regulate
FDA-approved GLP-1 receptor agonists include semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity)
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At the same time, reduced dosing may also influence how well treatment works
Weight maintenance during the switch is typical
