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These observations were also consistent with the incretin concept in which, in response to oral nutrients, glucoincretin hormones such as GIP (and subsequently GLP-1) originate from the gut and not the pancreas

The effects of liraglutide and dapagliflozin on cardiac function and structure in a multi-hit mouse model of HFpEF

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Makary, M

This mechanism extends feelings of fullness for hours after eating

Individual genetics influence baseline receptor expression, signaling efficiency, and potential side effect susceptibility, yet environmental factors, lifestyle, and overall health status remain equally important in determining clinical response