what is comparable to semaglutide Tirzepatide and key differences, weight loss results (2026) Tirzepatide vs Semaglutide | Best

2024 Dec;32(12):2255-2263

GLP-1 RAs, such as tirzepatide and semaglutide, have become widely used to treat obesity and type 2 diabetes

Those who are pregnant or breastfeeding may also want to avoid GLP-1 agonists, as the safety of these medications during pregnancy has not been well-established

Importantly, GLP-1 RAs also possess anti-inflammatory and neuroprotective properties, which are increasingly seen as relevant in the context of mood disorders [15,26]

In a 46week obesity trial, mean weight loss reached 14.9 percent at the highest dose, while in the MASH trial, improvement in MASH ranged from 43 percent to 62 percent depending on dose, with significant reductions in liver fat

Note: Certain medical conditions or medications may mean GLP-1 therapy is not right for you