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Loss of appetite is uncommon and may indicate pancreatitis

The 2006 human study that Protandim quoted above is only a half-truth: yes, there was a 40% decrease in oxidative stress in study subjects using the TBARS test (which is not considered to be a reliable marker.) The methodology was also a mess
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Filippatos TD, Derdemezis CS, Gazi IF, Nakou ES, Mikhailidis DP, Elisaf MS

In our clinics, some patients do report a positive increase in energy and mood which they find helpful with motivation to make healthier choices such as cooking at home versus eating out or going for regular walks instead of remaining sedentary

Nonetheless, while these agents are well-tolerated, they have some side effects, most importantly gastrointestinal, which warrant attention