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These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [1922], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]

GLP-1 side effects include nausea, diarrhea, and vomiting

J Diabetes Res 2019(9426014)

Nausea affects approximately 32% of patients, but this typically occurs early in treatment and resolves within weeks

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