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The 2024 joint scientific statement on nutrition and GLP-1 medications recommends involving a registered dietitian where appropriate, especially for people at risk of inadequate nutrient intake or muscle loss

doi: 10.1172/JCI990 24 GutzwillerJPDreweJGokeBSchmidtHRohrerBLareidaJet al

Semaglutide and Tirzepatide in Clinical Research Newer GLP-1 medications, especially semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro/Zepbound), have been the subject of significant clinical research

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Several pharmacological therapies used to treat nutritional obesity and metabolic dysfunction, or those that have targeted pathways disrupted due to pathogenic variants (eg, setmelanotide in POMC deficiency), have been trialed in patients with HO, with variable success limited to a small number of patients [54]
