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Circulating concentrations of GLP-1 cause the beta-cells in the pancreas to release insulin, which lowers blood glucose, and activity in various regions of the central nervous system reduces appetite and enhances satiety

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GLP 1 therapy helps control these risk factors at the root level

Given the clinical evidence reviewed above, patients with type 2 diabetes and/or obesity are the most promising candidate population to benefit from GLP-1RA-centered pharmacotherapy to improve cardiovascular and kidney outcomes

Sustained Weight Loss Following 12-Month Pramlintide Treatment as an Adjunct to Lifestyle Intervention in Obesity

In depth inclusion and exclusion criteria are also included in Table 1