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To capture cardiorenal outcomes in the full breadth of patients encountered in clinical practice, we may need to look beyond clinical trials to real-world evidence studies, in order to confirm that CVOT findings are consistent in more diverse populations reflective of patients in the clinic [73]

[DOI] [PubMed] [Google Scholar] 236.Orskov C., Wettergren A., Holst J.J

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They mimic natural GLP-1 but resist rapid breakdown by the enzyme DPP-4, providing sustained activity

Especially at concentrations of 10100 nM Liraglutide lead to a significant reduction in proliferation and DNA synthesis as observed in cell counting, MTS, 3-(4,5-di methylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) and [H]-thymidine incorporation assays [13, 20]