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It is well established that patients with diabetes demonstrate higher susceptibility to pancreatic cancer and pancreatitis compared to non-diabetic individuals, and theoretically, sustained GLP-1 receptor activation induced by GLP-1RA therapy may potentially elevate pancreatic cancer risk [8]

Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice

3 Wang, J., et al., Hyperandrogenemia and insulin resistance: The chief culprit of polycystic ovary syndrome

They also looked for issues that negatively affected the health of the fetus, including preterm birth (before 37 weeks), major birth defects (including of the kidneys, heart, and nervous system), stillbirth, and abnormal birth weight (both small and large)

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Additional signals have emerged from a cross-sectional analysis of the FDA Adverse Event Reporting System (FAERS) database (20032024)