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Long-term effects of intensive glucose lowering on cardiovascular outcomes

Habib AM, Richards P, Rogers GJ, Reimann F, Gribble FM

In preliminary experiments, active GLP-1(736) amide levels were lower in either peripheral or whole-blood samples than in portal blood samples even though blood was immediately treated with the DPP IV inhibitor

both treatments can support meaningful, sustainable weight loss , but they differ in how they act, likely outcomes, and practical considerations like cost and coverage

A 2024 review published in Circulation found that 20 to 50 percent of the total weight loss achieved on GLP-1 receptor agonists comes from lean muscle mass not fat tissue. The landmark STEP 1 trial data confirmed this, showing lean mass reduction of 6.92 kg in patients losing an average of 15.3 kg meaning approximately 45 percent of that weight was not fat at all, but metabolically active muscle. This distinction is not a minor footnote

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