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The combination therapy of GLP-1 receptor agonists and metformin demonstrates superior safety over monotherapy, while revealing novel adverse events and demographic-specific risk patterns, thereby offering reliable evidence to inform clinical practice.

Judicious use of semaglutide through appropriate patient selection and vigilance can mitigate some of its more serious side effects such as serious gastrointestinal symptoms, gallstone pancreatitis and exacerbation of depression

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