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Thus, access to the brain parenchyma for peripherally administered GLP1 receptor agonists via the ventricular system seems unlikely, though probably deserves further detailed experimental attention in order to produce an unequivocal answer

The kind that makes the first two days after injection miserable

Chaiyasate, The rise of ozempic face: analyzing trends and treatment challenges associated with rapid facial weight loss induced by GLP-1 agonists

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For weight management, reassessment should include evaluation of body composition changes rather than scale weight alone, as patients may be gaining muscle mass while losing fat, particularly if they have increased physical activity