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Post-transplant cardiovascular disease

This mechanism reduces hepatic glucose output and strengthens overall insulin signaling beyond single-receptor therapies

The slowed gastric emptying may delay melatonin absorption and alter its effectiveness, with this effect most apparent at the start of treatment or after dose increases

Physicians expect a rapid shift in prescribing patterns as cheaper generics make GLP-1 therapy accessible to a much broader segment of patients

Most athletes tolerate these medications without significant performance loss

Water retention, muscle gain from new exercise, hormonal fluctuations, and GI changes from the medication itself can all mask real progress in the short term