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Shi L, Ji Y, Jiang X, Zhou L, Xu Y, Li Y, Jiang W, Meng P, Liu X

In Phase 2 trials, treatment with survodutide led to greater reductions in both HbA1c levels and body weight compared to placebo after 16 weeks

The global prevalence of 537 million affected in the age group of 2079 years in 2021 will rise to 783 million in 2045, with the lowest increase in incidence in Europe (13%) and the highest in the African countries south of the Sahara (134%) ( Obesity, defined as a body mass index above 30 kg/m 2 , is also increasingly prevalent worldwide and has become a challenge to the various healthcare systems and societies

By contrast, routine initiation is generally not indicated for lean PCOS or for patients with low cardiometabolic risk, except in selected circumstances (e.g., specific metabolic indications) or within research protocols

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The concomitant use of alcohol or central nervous system (CNS) depressant drugs (e.g., barbiturates, benzodiazepines, and sleep medications) with phentermine or topiramate may potentiate CNS depression or other centrally mediated effects of these agents