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Hot flashes and night sweatsespecially in early menopausedisrupt sleep and increase cortisol, which promotes visceral fat storage and reduces GLP-1 medication effectiveness

The cumulative incidence of NAION was assessed using the Kaplan-Meier method and a Cox proportional hazards regression model to account for potential confounding factors

GLP-1-related hair loss typically peaks 24 months after the triggering event (usually rapid weight loss) and begins to resolve over the following 36 months

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4 Preclinical models demonstrate that GLP1 signalling influences hypothalamicpituitaryadrenal (HPA) axis activity and dopaminergic neurotransmission, supporting a mechanistic basis for effects on affective and compulsive behaviours

In trials, overall GI events rose with higher doses and faster escalations