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Starting low and increasing slowly over 20+ weeks helps minimize side effects while reaching target doses

Participants receiving the 2.4 mg weekly maintenance dose lost an average of 14.9 kg (approximately 15% of their starting weight), compared to just 2.6 kg in the placebo group

oral formulation (Rybelsus) also available Lixisenatide (Lyxumia) once-daily injection NICE guidance for type 2 diabetes (NG28) recommends GLP-1 receptor agonists in specific circumstances: typically as a third-line option when other treatments haven't achieved adequate glycaemic control, particularly in people with a BMI 35 kg/m (adjusted for ethnicity), or for whom weight loss would benefit other obesity-related comorbidities, or for whom insulin would have significant occupational implications

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These findings were confirmed in high-fat, high-cholesterol (HFHC) dietfed mice with functional LDL receptor deficiency induced by viral expression of proprotein convertase subtilisin/kexin type 9adeno-associated virus (PCSK9-AAV), in which daily administration of semaglutide for 18 weeks reduced aortic plaque area (11)

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