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Notably, both agents produced significant reductions in depression and asthma prevalence, accompanied by decreased antidepressant and asthma medication usage ( Tables S14S17 ), suggesting clinically meaningful improvement in symptomatic disease burden

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The tirzepatide doses of 10 and/or 15 mg demonstrated superiority compared to placebo for the coprimary endpoints percentage body weight reductions from baseline at week 72 and the proportion of patients achieving 5% body weight reduction at week 72

2b, Supplementary Fig

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Tirzepatide users may experience slightly higher rates of nausea due to its dual-action mechanism, though this varies widely among individuals