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Clinical outcome studies have demonstrated the therapeutic potential of GLP-1RAs and tirzepatide in mitigating MASH

Heres what helps long-term success: Regular doctor visits: Your doctor will check how youre doing and adjust your treatment as needed

Also, note non-scale victories these could include having more energy, clothes fitting better, or other improvements in your daily life

Glucagon-like peptide-1 (GLP-1) agonists have transformed weight loss treatments

Ozempic for Weight Loss Studies comparing Wegovy and Ozempic show both drugs are effective at helping patients diagnosed with obesity or overweight reduce their body weight, but Wegovy reduces weight more effectively than Ozempic does
The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss
