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The Lancet, 402(10396), 1617-1618

Native human GLP-1 has a very short half-life of approximately 2 minutes due to rapid degradation primarily by the enzyme dipeptidyl peptidase-4 (DPP-4), with neutral endopeptidase (NEP) also contributing to its breakdown

The constipation treatment strategies for tirzepatide work much better when titration is done properly from the start

If validated in adequately powered human trials, this would be a genuinely new mechanism for substance use disorders, rooted in metabolic signalling rather than monoamine modulation

We all have a unique genome, metabolism and microbiome

Once the underlying trigger is addressed, the hair usually begins to return to normal within six to 12 months. New