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This mechanism helps to stimulate insulin secretion when blood glucose levels are elevated, suppress glucagon release, slow gastric emptying, and reduce appetiteall contributing to improved glycaemic control

Mounting evidence suggests that the boom is being fuelled, at least in part, by self-prescription

10.2337/dc17-1902 10

Some of these agents can also slow intestinal glucose absorption through a modest inhibitory effect on SGLT1, and balanced dual SGLT1/2 inhibitors such as sotagliflozin have been developed that have metabolic and cardiorenal benefits [88]

But the mechanistic data is compelling enough that several research groups are exploring this avenue

Clinical research demonstrates that extended-interval dosing can deliver sustained appetite suppression when properly calibrated, though individual response varies based on metabolic factors and genetic predisposition