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At first, Wegovy was FDA-approved for chronic weight management when paired with exercise, dietary modifications, and increased physical activity in patients with obesity (body mass index 30 kg/m or more) and overweight (BMI 27 kg/m or more) with at least one weight-related health condition such as heart diseases, high blood pressure (hypertension), high cholesterol levels, type 2 diabetes, and sleep apnea

Chronic stress raises cortisol levels, which can interfere with weight loss and promote fat storage, especially around the midsection

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In a follow-up study, tadalafil restored urethral relaxation and detrusor contraction (Gotoh et al