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Sleep disturbances, including difficulty falling or staying asleep, have been reported by some trial participants, though a confirmed causal link has not yet been established

Note the pattern

These studies not only indicate a role for the gut microbiota in impacting gutbrain neuronal signaling, but also suggest that differential gut microbiomes could have varying effects

Compliance with Reporting Guidelines: The systematic review and meta-analysis were conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines

Due to inclusion criteria, all participants required secondary prevention of CV disease

CagriSema appears to partially prevent this adaptation, which could translate to more durable weight maintenance over time