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Key points to consider when choosing between them: Mechanism : Semaglutide targets GLP-1 receptors, while tirzepatide works on both GLP-1 and GIP receptors

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Abbreviations GLP-1RA: Glucagon-like peptide-1 receptor agonist(s) IPTW: Inverse probability of treatment weighting SGLT-2i: Sodium-glucose cotransporter 2 inhibitor(s) SIS: Suicidal ideation and self-injury VHS: Valencia Health System VID: Valencia Health System Integrated Database References Davies MJ, Aroda VR, Collins BS et al (2022) Management of hyperglycemia in type 2 diabetes, a consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

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